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Tao Shengce’s Team Identifies COVID-19 specific IgG and IgM responses

July 20, 2020      Author: Tao Shengce

On July 14, 2020, Tao Shengce team's team from Center for Systems Biomedicine, SJTU, Zhou Jie's team from Foshan No.4 People's Hospital and Men Dong's team from Wuhan Institute of Virology published cooperative findings in Nature Communications, titled "SARS-CoV-2 proteome microarray for global profiling of COVID-19 specific IgG and IgM responses".

Co-first authors of this research are Dr. Jiang Hewei, Dr. Li Yang, Dr. Zhang Hainan from SJTU and Doctor Wang Wei from Foshan No.4 People's Hospital. The corresponding authors are Researcher Tao Shengce from SJTU, President Zhou Jie from Fuoshan No.4 People's Hospital and Associate Researcher Men Dong from Wuhan Institute of Virology.


Link: https://www.nature.com/articles/s41467-020-17488-8



We still know very little about how the human immune system responds to SARS-CoV-2. Here we construct a SARS-CoV-2 proteome microarray containing 18 out of the 28 predicted proteins and apply it to the characterization of the IgG and IgM antibodies responses in the sera from 29 convalescent patients. We find that all these patients had IgG and IgM antibodies that specifically bind SARS-CoV-2 proteins, particularly the N protein and S1 protein. Besides these proteins, significant antibody responses to ORF9b and NSP5 are also identified. We show that the S1 specific IgG signal positively correlates with age and the level of lactate dehydrogenase (LDH) and negatively correlates with lymphocyte percentage. Overall, this study presents a systemic view of the SARS-CoV-2 specific IgG and IgM responses and provides insights to aid the development of effective diagnostic, therapeutic and vaccination strategies.


Translated by Han Yueyue    Reviewed by Wang Bingyu