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SJTU Researchers Developed Hydrogel Adhesive Speeding-up Oral Mucosal Wound Healing

October 20, 2021      Author:

Oral mucosal diseases, represented by oral ulcer, are common clinical diseases marked by recurring outbreaks. They often cause pain, seriously affecting the quality of life, as well as the physical and mental health of patients. Different from the skin on the body, the oral mucosa is exposed in a wet and highly dynamic environment, making local treatment of oral mucosal diseases rather challenging.

Prof. Zhu Linyong and Researcher Lin Qiuning's team of Shanghai Jiao Tong University cooperated with Prof. Jiang Xinquan's team of SJTU College of Stomatology and developed a photo-crosslinking hydrogel adhesive for oral mucosa repair that is inspired by the instantaneous completion of protein nitrosation reaction in vivo (S-nitrosation, a post-translational modification of protein) and operates on a fast (within 5 s) phototriggered S-nitrosylation coupling reaction.

The new hydrogel adhesive demonstrates good operability, excellent wet tissue adhesion and adaptive mechanical strength. It can adapt to the complex physiological environment of oral mucosa and provides new materials and new strategies for local treatment of oral mucosal diseases. It is expected to help patients get rid of the troubles caused by oral ulcer and other oral mucosal diseases.

The research results were published in Advanced Materials under the title of "Promoting Oral Mucosal Wound Healing with a Hydrogel Adhesive Based on a Phototriggered S-Nitrogenation Coupling Reaction". Dr. Zhang Wenjie from SJTU College of Stomatology, Dr. Bao Bingkun from SJTU, and Dr. Jiang Fei from SJTU College of Stomatology are the co-first authors. SJTU researcher Lin Qiuning, Prof. Jiang Xinquan from SJTU College of Stomatology, and Prof. Zhu Linyong from SJTU are the corresponding authors.

 

Author: Bao Bingkun

Source: School of Biomedical Engineering, SJTU

Translated by Zhou Rong

 

Abstract

The wet and highly dynamic environment of the mouth makes local treatment of oral mucosal diseases challenging. To overcome this, a photo-crosslinking hydrogel adhesive is developed inspired by the success of light-curing techniques in dentistry. The adhesive operates on a fast (within 5 s) phototriggered S-nitrosylation coupling reaction and employs imine anchoring to connect to host tissues. Unlike other often-used clinical agents that adhere weakly and for short durations, this thin, elastic, adhesive, and degradable cyclic o-nitrobenzyl-modified hyaluronic acid gel protects mucosal wounds from disturbance by liquid rinsing, oral movement, and friction for more than 24 h. The results from both rat and pig oral mucosa repair models demonstrate that this new gel adhesive creates a favorable microenvironment for tissue repair and can shorten tissue healing time. This study thus illustrates a therapeutic strategy with the potential to advance the treatment of oral mucosal defects in the clinic.