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SJTU Center of Hydrogen Science Made Progress in Hydrogen Medicine

July 22, 2021      Author:

Center of Hydrogen Science of Shanghai Jiao Tong University has achieved coordinated development in three research directions: hydrogen energy, hydrogen medicine and hydrogen agronomy. Hydrogen is not only a clean energy, but also a medical gas that has been proven safe and effective and has shown obvious anti-inflammatory effect against inflammation-related diseases. It is also a clean and efficient agricultural gas, which has significant biological effects in stress resistance, yield increase and preservation of crops. Inspired by hydrogen energy, Professor He Qianjun's team applied hydrogen energy and catalysis to hydrogen medicine and hydrogen agronomy, and made a series of new progress in 2021.

Firstly, to tackle the difficulty in controlling the release of hydrogen, the team developed a Z-scheme SnS1.68-WO2.41 nanocatalyst and a homogenous carbon/potassium-incorporation catalyst and put forward a "combined hole/hydrogen therapy", which effectively destroyed the tumor microenvironment and achieved a high-efficiency anti-cancer effect. The research results were published in Nature Communication under the title "The Photocatalysis-Mediated Drug-Free Sustainable Cancer Therapy Using Nanocatalyst" (Nature Communications, 2021, 12, 1345. Paper Link: https://doi.org/10.1038/s41467-021-21618-1) and in Advanced Materials under the title "Homogenous carbon/ potassium-incorporation strategy for synthesizing red polymeric carbon nitride capable of near-infrared-photocatalytic H2 production" (Advanced Materials, 2021, in press. Paper Link: https://doi.org/10.1002/adma.202101455).

Secondly, to tackle the difficulty of releasing hydrogen slowly with high efficiency, a hydrogen nanocapsule was designed and synthesized by encapsulating ammonia borane into hollow mesoporous silica nanoparticles to achieve ultrahigh and sustained H2 release in the gut. The research results were published in Biomaterials, titled "Nanocapsule-mediated sustained H2 release in the gut ameliorates metabolic dysfunction-associated fatty liver disease" (Biomaterials, 2021, 121030. Paper Link: https://doi.org/10.1016/j.biomaterials.2021.121030); and in Chemical Engineering Journal, titled "Nanomaterial-mediated sustainable hydrogen supply induces lateral root formation via nitrate reductase-dependent nitric oxide" (Chemical Engineering Journal, 2021, 405, 126905. Paper Link: https://doi.org/10.1016/j.cej.2020.126905).

The research work has received strong support and help from Professor Su Chenliang of Shenzhen University Institute of Microscale Optoelectronics, Associate Professor Lu Xifeng of Shenzhen University Health Science Center, and Professor Shen Wenbiao of Nanjing Agricultural University. The research was funded by the National Natural Science Foundation of China and the SJTU Center of Hydrogen Science.

 

Author: SJTU Center of Hydrogen Science

Source: School of Materials Science and Engineering, SJTU

Translated by Zhou Rong

Proofread by Xiao Yangning, Fu Yuhe