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Vascular Biology

Brief Introduction

The Shanghai Key Laboratory of Vascular Biology was established in 1999. It is located in the Science and Technology Building at Ruijin Hospital with advanced equipment and outstanding scientists. This laboratory is aimed to decipher the mechanisms of vascular adventitial remodeling in hypertension and characterize genetic defects related to cardiovascular disease. Currently, the main research directions include (1) detecting the early biomarkers for cardiovascular disease; (2) clarifying the pathophysiology and molecular mechanisms for cardiovascular remodeling; (3) identifying new pharmacological targets for cardiovascular disease. Moreover, this laboratory has already in receipt of the grants from the National Key Development Program on Basic Research, Chinese Ministry of Science and Technology and National Scientific Funding Category, Shanghai Commission of Science and Technology. Furthermore, we have successfully bridged bilateral cooperation with a wide range of international groups, including France, United States, Canada and Hong Kong.


Members

  • Director: Gao Ping-Jin, Professor
  • Professor Gao Ping-Jin is Head of the Department of Hypertension at Ruijin Hospital, Jiao Tong University School of Medicine and Vice Director of Shanghai Institute of Hypertension, as well as Director of Shanghai Key Laboratory of Vascular Biology in Shanghai. She respectively received her Doctor of Medicine and Philosophy in 1986 and 1994 from Shanghai Second Medical University (Currently Shanghai Jiao Tong University School of Medicine). As a major researcher, she visited the Centre National de la Recherche Scientifique (CNRS, Paris, France) during 1995-1999 for bilateral cooperation program on hypertension.

    Her main research interest is centered on (1) detecting the early biomarkers for cardiovascular disease; (2) clarifying the pathophysiology and molecular mechanisms for cardiovascular remodeling; (3) identifying new pharmacological targets for cardiovascular disease. So far, Professor Gao has obtained two National High Technology Plan (863 program), two National Key Program and four National Natural Science Foundation.

    Award:

    2003             The Second Prize of Shanghai Medicine Award

    2004             The Second Prize of Shanghai Scientific Technology Progress

    2004             The First Prize of Chinese Medical Award

    2008             The Third Prize of Shanghai Scientific Technology Progress

  • Director of Academic Committee: Zhu Ding-Liang, Professor
  • Professor Zhu Ding-Liang is Director of Shanghai Institute of Hypertension, the Vice Director of State Key Laboratory of Medical Genomics at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, and the principal investigator of the Sino-French Research Center for Life Science and Genomics. He received his Doctor of Medicine from the Second Army Medical University in 1966 and his Doctor of Philosophy from Université Pierre et Marie Curie - Paris VI in 1992. Further, Professor Zhu studied as a visiting scholar in Department of Cell Biology at North Carolina State University during 1986-1988. He completed his study for Doctor of Philosophy and postdoctoral research in Institute National de la Santé et de la Recherche Médicale (INSERM) and Centre National de la Recherche Scientifique (CNRS) during 1988-1995.

    His main research interest has focused on: (1) the establishment of hypertension resources and genetic studies on hypertension with his current endeavor being the genome wide association study; (2) the mechanism of vascular remodeling in hypertension; (3) the genetic diagnosis of secondary hypertension; (4) the screening and discovery of new biomarkers with his current focus on the community-based prospective study on the risk factors and genetic markers for hypertension and its complications.

    So far, Professor Zhu has already in receipt of more than twenty research grants from the National Key Development Program on Basic Research, Chinese Ministry of Science and Technology and National Scientific Funding Category, and Shanghai Commission of Science and Technology. He has a publication record of more than 60 SCI papers and achieves two patents.

  • Team Members
  • At present, our study group is composed of nine senior research scientists, four middle-level researchers, and two junior researchers. Thereof, nine of them have already obtained their Ph.D. or M.D degree. In addition, we have 7 associate professors including Shen Weili, Zhang Yi, Guo Shujie, Zhao Jianxing, Wu Shengnan, Wu Yongjie and Zhu Limin.


    Research Fields

  • to detect the early biomarkers for cardiovascular disease;
  • to clarify the pathophysiology and molecular mechanisms for cardiovascular remodeling;
  • to identify new pharmacological targets for cardiovascular disease.

  • Research Achievements

  • Role of adventitia in the vascular remodeling of cardiovascular diseases
  • The Third Prize of 2008Shanghai Scientific Technology Progress

    Vascular Biology

  • Establishment of genetic biobank related to hypertension
  • The First Prize of 2004 Chinese Medical Award

    Vascular Biology


    Cooperation

  • University of Rocheste, USA
  • Chinese University of Hong Kong, Hong Kong
  • INSERM "Gene and blood pressure", France
  • University of Manitiba, Canada