Shanghai Key Laboratory of pancreatic disease was established in 2005 by Shanghai Science and Technology Committee. It is located at First People's Hospital affiliated with Shanghai Jiao Tong University. The task of our laboratory is to facilitate innovative research into the biology and therapeutic method of pancreatic cancer and pancreatitis. The current director of laboratory is Professor Wang Liwei, who is also the executive officer and chief physician of medical oncology department, Shanghai NO.1 People's Hospital. The Laboratory currently has 24 faculty and staff members, including 15 senior researchers. Meanwhile, the Laboratory is well equipped with five pieces of instruments valued more than 100 thousand yuan. It has received 18 grants, one of which is at national level. The laboratory's research has been focused on two kinds of disease: (1) pancreatic cancer: with the aim to investigate the epidemiology, early diagnosis and prevention of pancreatic cancer by basic cancer research and translational research, to identify biomarkers for pancreatic cancer early diagnosis, therapeutic efficiency and prognosis and to develop novel and specific cancer therapies, including both individualized treatment and molecular target therapy approaches. (2) pancreatitis: to explore the molecular mechanism involved in the acute necrotizing pancreatitis, especially to elucidate the function of Inflammatory mediators involved in the disease, and to optimize the procedure of clinical treatment of acute necrotizing pancreatitis. In recent years, the Lab has won more than ten research grants supported by Science and Technology Commission of Shanghai Municipality or National Science and Technology Support Plan.
Professor Wang Liwei
- Director of Academic Committee
Professor Gu Jianren
- Team Members
Professor Qiu Zhengjun, Professor Zhu Qi, Professor Xu Min, Professor Huang Qian, Professor Yu Yongtao, Dr. Li Lei, Dr. Li Qi, Dr. Huang Chen
- Pancreatic cancer stem cells
- Mechanism of pancreatic cancer infiltration and metastasis
- New targets of pancreatic cancer therapy
- Application of Bioinformation technology in pancreatic cancer research
- Mechanism of severe acute pancreatitis and chronic pancreatitis and pancreatic fibrosis
- Shanghai Science and Technology Progress Award, 3rd degree, 2008
- Lentivirus-mediated shRNA interference targeting STAT3 inhibits human pancreatic cancer cell invasion. Yang G, Huang C, Cao J, Huang KJ, Jiang T, Qiu ZhengJun, World J Gastroenterol.2009, 15(30): 3757-3766
- PTK787/ZK22258 attenuates stellate cell activation and hepatic fibrosis in vivo by inhibiting VEGF signaling. Liu Y, Lui EL, Friedman SL, Li Lei, et al, Lab Invest, 2009, 89(2): 209-221
- Regulation and functional role of eEF1A2 in pancreatic carcinoma. Cao H, Zhu Q, Huang J, Li Baiwen, et al., Biochem Biophys Res Commun, 2009, 380(1):11-16
- CD4+ T-cell-mediated anti-tumor immunity can be uncoupled from autoimmunity via the STAT4/STAT6 signaling axis. Zhang Sheng, Bernard D, Khan WI, Kaplan MH, Bramson JL, Wan Y., Eur J Immunol, 2009, 5(39):1252-1259
- The role of CD4 T cell help for CD8 CTL activation, Zhang Sheng, Zhang H, Zhao J. Biochem Biophys Res Commun, 2010, 384(4):405-408
- Nitric Oxide and Pancreatic Cancer Pathogenesis, Prevention, and Treatment, Wang Liwei, Xie K., Current Pharmaceutical Design, 2010, 16(4):421-427.
- Oncolytic adenovirus delivering herpes simplex virus thymidine kinase suicide gene reduces the growth of human retinoblastoma in an in vivo mouse model, Ji X, Zhang J, Cheng L, Wei F, Li H, Liu X, Chen X, Li C, Wang Y, Huang Qian, Exp Eye Res 2009, 89(2):193-9 2.579
- Non-invasive visualization of retinoblastoma growth and metastasis via bioluminescence imaging, Ji X, Cheng L, Wei F, Li H, Wang M, Tian Y, Chen X, Wang Y, Wolf F, Li C, Huang Qian, Investigative Ophthalmology & Visual Science, 2009, 50(12):5544-5551.
- Novel strategies to augment genetically delivered immunotoxin molecular therapy for cancer therapy, Liu X, Wu J, Zhang S, Li C, Huang Qian, Cancer Gene Ther, 2009, 16:861-876.
The twin cancer center with The university of Kentucky Markey Cancer Center
MD Anderson Cancer Center
Shanghai Cancer Research Institute
Shanghai Center for Bio-information Technology
Chinese National Human Genome Center at Shanghai