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MOE Key Laboratory for Cell Differentiation and Apoptosis

Brief Introduction

The MOE Key Laboratory for Cell Differentiation and Apoptosis was established in 2005. Among the 50 staff members, there are eight professors and 14 associate professors, with the average age of 35. About 60% of the staff members have a Ph.D. degree and oversea working experiences. We have nearly 70 research projects including "973", "863" and grants from National Natural Science Foundation and Shanghai Committee of Science and Technology. During last seven years we have published over 80 papers in peer-reviewed journals such as BLOOD, LEUKEMIA, JBC, and ONCOGENE, which are leading journals in haematology and oncology. We have also received the first prize of Chinese Medical Science and Technology, the first prize of Shanghai Scientific and Technological Progress and the first prize of Shanghai Natural Science Prize.


Members

  • Director: Chen Guoqiang
  • Director of Academic Committee: Lin Qishui
  • Team Members: Yi Jing, Wu Ji, Wang Yibin, Zhao Qian, Fu Guohui, Cheng Jinke, Liu Junling, Feng Lixin, Zhuang Hanyi, Hong Dengli, Deng Jiong, Zhang Jian, Wang Lishun, and Wu Yingli.

  • Research Fields

  • Tumor chemical biology and proteomics research;
  • Leukemia cell differentiation and death signaling mechanisms and drug target research;
  • Medical stem cell biology;
  • Computational biology and drug design;
  • Olfactory receptor system research.

  • Research Achievements

  • First prize of Shanghai Scientific and Technological Progress in 2008 (Completed by: Chen Guoqiang, Wu Yingli, Lu Ying, Zhao Kewen, Liu Wei)
  • Cell Differentiation and Apoptosis Lab

  • First prize of Chinese Medical Science and Technology in 2005
  • (Completed by: Chen Guoqiang, Zhao Qian, Zhao Kewen, Huang Ying, Jiang Yi, et al)

    Cell Differentiation and Apoptosis Lab

  • In the research field of "Hypoxia and hypoxia-mimetic agents induce acute myeloid leukemic cell differentiation", we have published 18 papers in peer-reviewed international journals, of which 11 are published in the journals with Impact Factor higher than five, including three in BLOOD (Impact Factor: 10.432) and four in LEUKEMIA (Impact Factor: 8.634). One of the papers:
  • Liu W, Guo M, Xu YB, Li D, Zhou ZN, Wu YL, Chen Z, Kogan SC, Chen GQ. Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia. BLOOD, 2006. 107, 2. 698-707.


    Scientific Collaboration

  • Cooperation with Harvard Medical School: nerve regeneration.
  • The Major International (Regional) Joint Research Program of China: discovery and mechanism study of key genes involved in leukemia cell differentiation, cooperation with the Scripps Research Institute
  • Cooperation with Shanghai Children's Medical Center: childhood leukemia.
  • Cooperation with Kunming Institute of botany, Chinese Academy of Sciences: chemical biology.