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SJTU Team Made Progress on the Effect of Biomimetic Chirality Hydrogel on Cell Adhesion

May 02, 2018      Author: Liu Jinying

Recently, the Angewandte Chemie International Edition published an online paper entitled The Cooperative Effect of both Molecular and Supramolecular Chirality on Cell Adhesion, revealing critical progress on the effect of biomimetic chirality hydrogel on cell adhesion, done by professor Feng Chuanliang team with School of Material Science and Engineering, SJTU. Doc. Liu Jinying is the first author of the paper, and Professor Meng Chuanliang is the corresponding author. This work was supported by the National Natural Science Foundation of China (NSFC 51573092), the Innovation Program of Shanghai Municipal Education Commission, and the Program for Professors of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning.

Although helical nanofibrous structures have great influence on cell adhesion, the role played by chiral molecules in these structures on cells behavior has usually been ignored. The chirality of helical nanofibers is inverted by the odd–even effect of methylene units from homochiral l‐phenylalanine derivative during assembly. An increase in cell adhesion on left‐handed nanofibers and weak influence of cell behaviors on right‐handed nanofibers are observed, even though both were derived from l‐phenylalanine derivatives. Weak and negative influences on cell behavior was also observed for left‐ and right‐handed nanofibers derived from d‐phenylalanine, respectively. The effect on cell adhesion of single chiral molecules and helical nanofibers may be mutually offset.

 


Translated by Liu Yixuan

 

Reviewed by Wang Bingyu