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New Mechanism to Promote Angiogenesis is Revealed by SJTU Research Group

September 06, 2017      Author: Zhang Bing

On Aug 29, article titled "VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis" by Researcher Zhang Bing's research group from SJTU Shanghai Center for Systems Biomedicine was published online on the well-known international academic journal the Nature Communication. The study points out that the new angiogenesis mechanism is enabled by VEGF controlling the RNAPII's stasis-release through the acetylated ETS1 transcription factor, indicating the importance of the RNAPII's stasis-release in angiogenesis for the first time in a systematic way.

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The article is first-authored by postgraduate Chen Jiahuan, Assistant Researcher Fu Yi and Daniel S. Day from Harvard Medical School and co-authored by William.T.Pu from Harvard Medical School and Researcher Zhang Bing. SJTU Shanghai Centre for Systems Biomedicine is the primary affiliation. The project is funded by National Natural Science Foundation, Youth Youth Program and Scientist Development Grant of American Heart Association.

 

 


Tranlated by Zheng Mengyan             Reviewed by Wang Binyu