Recently, Ping Yong Research Group in Bio-X Center of Shanghai Jiao Tong University(SJTU) used drosophila as the model organism and established Alzheimer Drosophila Model, aka. "senile dementia drosophila", with the unique GAL4-UAS transgene system of drosophila. This model provides strong evidence for explanations on the pathogenic mechanism of Alzheimer's disease. Progress in the research was published on the latest Molecular Neurobiology(DOI: 10.1007/s12035-016-0165-z). Main research work has been completed by two graduate students-Song Qian(who has already graduated) and Feng Ge. These research outcomes provide explanations for possible pathogenic mechanisms of Alzheimer, and potential targets for treatment of this disease.
Translated by Zhang Yifan Reviewed by Lu Siyu