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SJTU Team Made Breakthrough in Toxin-Antitoxin (TA) System Research

March 26, 2018      Author:

Recently, the Nucleic Acids Research, a prestigious journal in molecular biology, and the Molecular Microbiology, classic journal in microbiology successively published two papers on the bioinformatics and experiment research of toxin-antitoxin system written by Ou Hongyu's research team, headed by Deng Zixin, State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, SJTU. The papers further elucidated the molecular mechanisms of drug resistance gene transfer and formation of retained cells in Klebsiella pneumoniae.

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Ou Hongyu's research team has long been researching on mobile genome of drug-resistant bacteria. His team has discovered that carbapenem gene blaKPC-2 can spread in ST11 type Klebsiella pneumoniae via composite transposons Tn1721-Tn3 (Journal of Antimicrobial Chemotherapy,2015), sub-inhibitory concentration of β-lactam drugs can enhance the interbacterial antagonism of the Klebsiella pneumoniae type 6 secretory system and that resistance plasmid that carries blaDHA-1, third -generation cephalosporin resistance gene, can make conjugational transfer in Klebsiella pneumonia type ST23, a highly pathogenic strain. Following these discoveries, the two newly published papers mark systematic progress in the research on the spread of Klebsiella pneumonia resistance.

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The research is funded by National Natural Science Foundation of China and Ministry of Science and Technology, China (973 program).



Links of papers:

https://academic.oup.com/nar/article/46/D1/D749/4584634

https://onlinelibrary.wiley.com/doi/abs/10.1111/mmi.13934

 

Translated by Chen Wanrong    Reviewed by Wang Bingyu