Researchers from Shanghai Jiao Tong University have confirmed that As2O3 can obviously restrain the activity of HK2: hexokinase-20 in tumor cells so as to influence the cell metabolism, resulting in apoptosis of tumor cells. This research achievement has been published on PNAS on November 23.
With concerted efforts of several generations of scientists, As2O3 has made an obvious success on the treatment of APL, the target spot and molecular mechanism of the drug have been illuminated. Except for APL, plenty of existing researches has proved that As2O3 has great potentiality in treating various malignancies, but relevant mechanism is not clear yet. As2O3 may play various roles in cells, so with High-Throughput Technology, it would be an effective strategy if the mechanism can be revealed at the system level.
This research is supported by National High Technology Research and Development Program of China (863 Plan) and natural science funds. Dr. Zhang Hainan, Dr. Yang Lina from School of System Biomedicine, SJTU and Professor Ling Jianya from Shandong University are all the first authors of this paper. Tao Shengce, a researcher from School of System Biomedicine, SJTU, and Chen Zhu, an academician from Ruijin Hospital, are corresponding authors of this article. Tao's primary domain of research is the exploitation and application of protein chip and a technology platform for series of protein chips has been established and applied to systematic study of relevant major scientific problems in medicine and clinical medicine.
Translated by Li Ying Reviewed by Wang Bingyu