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Research team from School of Biomedical Engineering, Shanghai Jiao Tong University makes great progress in Monomolecular Nanobiology. By integrating AFM monomolecular mechanics experiment with analog computation, the research team explored the pore created by PFO on cell membrane and further proposed a new mechanism on proteins configuration transformation under internal force. The new mechanism provides general significance for researches on congeneric proteins as well as researches on new drug target. Relative research findings were published in eLife recently.
Experiments results provide not only a clear physical model for PFO configuration transformation, but also a new mechanism on long-distance transmission of intramolecular force within macromolecules. Intramolecular force can serve as key factor which drives the macromolecular configuration transformation of proteins. The new mechanism provides general guidance on congeneric molecules researches. Furthermore, this research project points out the critical amino acid in PFO and proposes new targets for drug researches.
This research project is co-sponsored by NSFC (Natural Science Foundation of China), STCSM (Science and Technology Commission of Shanghai Municipal), Pujiang Talent Plan, K.C. Wong Education Foundation. Senior Fellow D.M. Czajkowsky is the first author, Prof. SHAO Zhifeng is the corresponding author, Researcher SUN Jielin and Dr. SHEN Yi are co-authors.
Translated by Wang Yifan Reviewed by Wang Bingyu