Lately, the joint research founding "High-throughput screening of rare metabolically active tumor cells in pleural effusion and peripheral blood of lung cancer patients" of SJTU Biomedical research institute and SJTU affiliated Shanghai Chest Hospital, school of Medicine of UCLA, was published on the PNAS. The research propose a new high-throughput screening method of tumor cell in pleural effusion, peripheral blood and other liquid samples, and its reliability can be confirmed by a large number of single cell sequencing. The research provides a new approach to identify malignant cells in complex body fluid samples. Their approach may serve as a valuable complement to cytology in MPE diagnosis, helping identify the driver oncogenes and resistance-leading mutations for targeted therapies. Lu Shun, the Director of Oncology Department of Shanghai Chest Hospital, is the joint correspondence author of the paper, and Li Ziming, attending doctor of Oncology Department is the co-first author.
Translated by Yue Jianfeng Reviewed by Wang Bingyu