The State Key Lab Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University made great breakthrough in bionic chirality supermolecule hydrogel, the result of which was published in two papers of Angew. Chem. Int. Ed. One of the two papers was choosen to be the cover essay. The first author is Dr. Liu Guofeng and the corresponding author is Pro. Feng Chuanliang.
This research developed the Chiral controllable supermolecule hydrogel system. They found that supermolecule chirality self-assembly package could be regulated by achirality molecule and nanofiber structure's chirality could affect the interaction between cell, biomolecule and materials while the further functional chirality structure enabled the self-assembly package to regulate and control cells' behavior intelligently. This research not only helped to learn the origin of stereoselectivity in life system, but also valued in biological medicine health.
The study about ECM chirality's regulation to histocyte was still at the exploration stage. And the key point to solve the problem is how to design the molecular structure to build bionic gel metarial with chirality characteristic and study its interaction to cell and biomolecule.
To solve these scientific problems, the Lab introduced the functionalization concept to the design of supermolecule gel molecular structure and built controllable, functional and intelligent bionic nanofiber self-assembly. The chirality supermolecule gelator based on C2 characterized with designable modules. Besides, the moisture content of the gel had a wide range, reaching 99.94% at the most with 10-80 micrometer loose structure to meet cells' need for growing space. And its mechanical strength was regulatory. They found that supermolecule chirality self-assembly package could be regulated by achirality molecule which was the theoretical support for achirality factors' influence to chirality structure. This paper was published in Angew. Chem. Int. Ed. （2016, DOI: 10.1002/anie. 201510140R1）as the cover paper.
The other research provided theoretical basis and new ways of thinking to bionic chirality micro-nano structure and preliminary solved the basic scientific problems bout the chirality nanofiber's regulation to cell adhesion and growth. It was published in Angew. Chem. Int. Ed. 2014, 53, 7789-7793.
Above researches showed that it was feasible to develop chirality controllable hydrogel system and the chirality of the nanofiber could affect the interaction between cell, biomolecule and materials. The further functionalization of chirality structure could realize the regulation to cell behavior, which had significant meaning for new biomaterial and devices' design and development.
Translated by Ling Jie Reviewed by Wang Bingyu