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【SHINE】Multifunctional coatings shot in the arm for cell-based therapy

March 02, 2021      Author: Cai Wenjun

Multifunctional coatings can greatly enhance the effects of cell-based therapy, local medical professionals announced today based on their experiments.

Surface coating of living cells can be an effective tool in cell‐based therapy. In an experiment where probiotics were coated with polydopamine and chitosan for colitis treatment, the coated cells showed a strong ability to defend against erosion from gastric jounce and bile, more than 30 times more bioavailability in the gut and four times more accumulation in the inflamed tissue than those of uncoated bacteria, according to Dr Liu Jinyao of Renji Hospital affiliated to Shanghai Jiao Tong University School of Medicine, the leading researcher of the study.

Multifunctional coatings present a robust platform for developing multimodal cells for enhanced cell‐based therapy. The method can be used on a diverse array of cells, including bacteria, fungi and mammalian cells, to improve the effects of cell therapy, Liu said.

 

The research was published by the journal Advanced Materials.

Source: SHINE  

Abstract of the research article:

Surface decoration of living cells by exogenous substances offers a unique tool for understanding and tuning cell behaviors, which plays a critical role in cell‐based therapy. Here, a facile yet versatile approach for decorating individual living cells with multimodal coatings is reported. By simply co‐depositing with dopamine under a cytocompatible condition, various functional small molecules and polymers can be encoded to form a multifunctional coating on a cell's surface. The accessibility and versatility of this method to decorate diverse cells, including bacteria, fungi, and mammalian cells is demonstrated. With the ability to tune surface functions, ligand co‐deposited gut microbiota is prepared as oral therapeutics for targeted treatment of colitis. Given the dual cytoprotective and targeting effects of the coating, decorated cells show more than 30‐times higher bioavailability in the gut and fourfold higher accumulation in the inflamed tissue in comparison with those of uncoated bacteria. Multimodal therapeutic cells further validate strikingly increased treatment efficacy over clinical aminosalicylic acid in colitis mice. Decorating with multifunctional coatings proposes a robust platform for developing multimodal cells for enhanced cell‐based therapy.