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SJTU Researchers Made Progress in Xylose Biosensor Design and Optimization

October 19, 2020      Author: Zhao Xiniqing

Recently, ACS Synthetic Biology, a top journal in synthetic biology, published a cooperative research by Prof. Zhao Xinqing from , SJTU, and Prof. Hal Alper from University of Texas at Austin, titled “Design, evolution, and characterization of a xylose biosensor in Escherichia coli using the XylR/xylO system with an expanded operating range”. The two professors are the corresponding authors; doctoral student Tang Ruiqi under the supervision of Prof. Zhao Xinqing as well as Prof. Bai Fengwu is the first author.

Their work expanded the operating ranges of the far-too-sensitive xylose biosensors and identified a less-sensitive and less-used biosensor for real applications, thus providing new insights into strategies for the evolution of other biosensors. Progress was also made in obtaining metabolizing enzyme genes from monosaccharide from fecal metagenome of ruminant and herbivore animals. The enzyme genes obtained could enhance biorefinery efficiency after being used in the construction of high-efficiency biotransformation microbial recombinant strain.

Their research has been sponsored by Key Program of National Natural Science Foundation of China (No. 21536006), and State Key Laboratory of Microbial Metabolism Open Projects Fund (No. MMLKF19-01).

 

Link: https://doi.org/10.1021/acssynbio.0c00225

 

Author: Zhao Xinqing

Affiliation: School of Life Sciences and Biotechnology, SJTU

 

Translated by Zhang Wenying

Proofread by Xiao Yangning, Fu Yuhe